Pinealon-  (also spelled Pinealone) is a synthetic tripeptide (Lys-Glu-Asp) with neuroprotective, anti-aging, and cognitive-enhancing effects.
Originally developed in Russia, it is researched for the following effects
Slow brain aging
Improve memory, and 
Support neuronal repair
 
Nasal spray delivery is gaining interest because of its direct pathway to the brain (via the blood-brain barrier and olfactory nerves), potentially enhancing bioavailability compared to oral or injectable routes.
 
1. How Pinealon Works
Mechanism:
Reduces oxidative stress in neurons
Enhances neuroplasticity (learning & memory)
May stimulate telomerase activity (anti-aging effect)
Modulates glutamate receptors (neuroprotection. 
 
Pinealon Nasal Spray Researched Dosage & Protocol
Since Pinealon is not FDA-approved, dosing is based on Russian clinical studies, and peptide clinic protocols.
Common Dosage Ranges:
Form
Dosage
Frequency
Cycle Length
Nasal Spray
100–300 mcg (0.1–0.3 mg)
1–2x daily
10–30 days
Subcutaneous Injection
2–5 mg/day
1x daily
10–20 days
Oral (Less Effective)
5–10 mg/day
1–2x daily
Low absorption
 
Used for 10–30 days, followed by a break (to prevent receptor desensitization)
Best taken in the morning or before cognitive work
 
3. Effectiveness: Nasal vs. Injection
Factor
Nasal Spray
Injection
Bioavailability
~30–50% (estimated)
~80–100%
Brain Uptake Speed
Faster (direct pathway)
Slower (systemic)
Convenience
No needles
Requires injections
Reported Effects
Subtle but noticeable
Stronger (studies)
 
Injection may be better for stronger neuroprotective effects (e.g., post-stroke recovery).
 
4. Benefits of Pinealon
Anti-brain aging (may slow cognitive decline)
Memory & focus improvement (anecdotal reports)
Neuroprotection after injury/stroke (Russian studies)
Mild anti-anxiety & mood stabilization